| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Optimal proteome allocation and the temperature dependence of microbial growth laws
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| Autores: |
Mairet, Francis
Gouzé, Jean-luc
De Jong, Hidde
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| Data: |
2021-03
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| Ano: |
2021
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| Resumo: |
Although the effect of temperature on microbial growth has been widely studied, the role of proteome allocation in bringing about temperature-induced changes remains elusive. To tackle this problem, we propose a coarse-grained model of microbial growth, including the processes of temperature-sensitive protein unfolding and chaperone-assisted (re)folding. We determine the proteome sector allocation that maximizes balanced growth rate as a function of nutrient limitation and temperature. Calibrated with quantitative proteomic data for Escherichia coli, the model allows us to clarify general principles of temperature-dependent proteome allocation and formulate generalized growth laws. The same activation energy for metabolic enzymes and ribosomes leads to an Arrhenius increase in growth rate at constant proteome composition over a large range of temperatures, whereas at extreme temperatures resources are diverted away from growth to chaperone-mediated stress responses. Our approach points at risks and possible remedies for the use of ribosome content to characterize complex ecosystems with temperature variation.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00686/79829/82633.pdf
https://archimer.ifremer.fr/doc/00686/79829/82634.pdf
https://archimer.ifremer.fr/doc/00686/79829/82635.pdf
DOI:10.1038/s41540-021-00172-y
https://archimer.ifremer.fr/doc/00686/79829/
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| Editor: |
Springer Science and Business Media LLC
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| Formato: |
application/pdf
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| Fonte: |
Npj Systems Biology And Applications (2056-7189) (Springer Science and Business Media LLC), 2021-03 , Vol. 7 , N. 1 , P. 14 (11p.)
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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